Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus
S Kramer-Hämmerle, I Rothenaigner, H Wolff, JE Bell… - Virus research, 2005 - Elsevier
The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1
infection of the central nervous system (CNS) or the occurrence of HIV-associated …
infection of the central nervous system (CNS) or the occurrence of HIV-associated …
HIV-1 target cells in the CNS
SB Joseph, KT Arrildt, CB Sturdevant… - Journal of …, 2015 - Springer
HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …
Regulation of neural cell survival by HIV-1 infection
Infection by the lentivirus, human immunodeficiency virus type 1 (HIV-1), results in a variety
of syndromes involving both the central (CNS) and the peripheral (PNS) nervous systems …
of syndromes involving both the central (CNS) and the peripheral (PNS) nervous systems …
Human immunodeficiency virus type 1–infected monocytic cells can destroy human neural cells after cell‐to‐cell adhesion
M Tardieu, C Héry, S Peudenier… - Annals of …, 1992 - Wiley Online Library
Primary cultures of human embryonic neurons and astrocytes have been used to test the
interactions between neural cells and either human immunodeficiency virus type 1 (HIV‐1) …
interactions between neural cells and either human immunodeficiency virus type 1 (HIV‐1) …
Human immunodeficiency virus (HIV)-induced disease of the central nervous system: pathology and implications for pathogenesis
H Budka - Acta neuropathologica, 1989 - Springer
Significant contributions from many different groups during the last 2 or 3 years have
characterized relatively uniform neuropathological changes of the CNS in AIDS patients …
characterized relatively uniform neuropathological changes of the CNS in AIDS patients …
Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of: in situ: polymerase chain reaction and …
O Bagasra, E Lavi, L Bobroski, K Khalili, JP Pestaner… - Aids, 1996 - journals.lww.com
Objectives: The majority of HIV-1-infected individuals manifest a plethora of central nervous
system (CNS) diseases unrelated to opportunistic infections, including AIDS dementia …
system (CNS) diseases unrelated to opportunistic infections, including AIDS dementia …
CD4-independent, productive infection of a neuronal cell line by human immunodeficiency virus type 1
XL Li, T Moudgil, HV Vinters, DD Ho - Journal of Virology, 1990 - Am Soc Microbiol
One neuronal cell line (SK-N-MC) was found to be susceptible to productive infection by
multiple isolates of the human immunodeficiency virus type 1 (HIV-1). Characterization of SK …
multiple isolates of the human immunodeficiency virus type 1 (HIV-1). Characterization of SK …
Breaking down the barrier: the effects of HIV-1 on the blood–brain barrier
M Strazza, V Pirrone, B Wigdahl, MR Nonnemacher - Brain research, 2011 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) primarily infects CD4+ T cells and cells of the
monocyte–macrophage lineage, resulting in immunodeficiency in an infected patient. Along …
monocyte–macrophage lineage, resulting in immunodeficiency in an infected patient. Along …
The neuropathogenesis of HIV-1 infection
HE Gendelman, SA Lipton, M Tardieu… - Journal of Leucocyte …, 1994 - academic.oup.com
HIV infection in brain revolves around productive viral replication in cells of mononuclear
phagocyte lineage, including brain macrophages, microglia, and multinucleated giant cells …
phagocyte lineage, including brain macrophages, microglia, and multinucleated giant cells …
Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection
HIV associated neurocognitive disorders and their histopathological correlates largely
depend on the continuous seeding of the central nervous system with immune activated …
depend on the continuous seeding of the central nervous system with immune activated …