Objectives: This study evaluated whether a xanthine oxidase (XO) inhibitor, oxypurinol,
produces clinical benefits in patients with New York Heart Association functional class III to …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

Background—Hyperuricemia is common in chronic heart failure (CHF), and it is a strong
independent marker of prognosis. Upregulated xanthine oxidase (XO) activity and impaired …

BACKGROUND: Previous studies have not extensively examined the association of
hyperuricemia and adverse outcomes in systolic heart failure (HF) in relation to xanthine …

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are
seen in patients who have worse ventricular function, functional capacity, and prognosis …

OBJECTIVE: Uric acid (UA) levels are frequently increased in patients with heart failure (HF),
and may be an indicator of a poor prognosis and an innovative target for treatment. We …

Increasing evidence suggests that serum uric acid (UA), a product of xanthine oxidase (XO),
may be a useful marker for metabolic, hemodynamic, and functional staging in heart failure …

We investigated the clinical profiles associated with serum uric acid (sUA) levels in a large
cohort of patients hospitalized for worsening chronic heart failure with ejection fraction …

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …