Objective: The aim of the present review is to give an overview about the role, biosynthesis,
and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular …

The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …

Podophyllotoxin (PTOX) is a biologically active compound derived from the podophyllum
plant, and both it and its derivatives possess excellent antitumor activity. The PTOX …

Background Recently, biologically active compounds isolated from plants used in herbal
medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely …

Cancer is one of the leading groups of threatened caused by abnormal state cell growth and
second leading diseases involved in the major global death. To treat this, research looking …

Podophyllotoxin, one of the well-known naturally occurring aryltetralin lignans, has been
used as the leadcompound for the preparation of potent anticancer agents, such as …

Podophyllotoxin is an important and much sought after antimitotic natural lead compound,
since it paved the way for three hemisynthetic derivatives of podophyllotoxin, eg, etoposide …

Podophyllum hexandrum Royle of family Berberidaceae is an endangered medicinal plant.
Rhizome of P. hexandrum contains several lignans which posses antitumor activity …

The aryltetralin-type lignan podophyllotoxin, the main agent present in the resin extracted
from the rhizomes of different podophyllum species, possesses important antineoplastic and …

Introduction: Podophyllotoxin (PPT) is a naturally occurring antimitotic agent and an
interesting lead in the development of anticancer agents. Its optimization led to the …