Here we investigated a pharmacological approach to inhibit spermatogenesis in the mouse
model by manipulating retinoid signaling using low doses of the pan-retinoic acid receptor …

Oral administration of a retinoic acid receptor (RAR) pan-antagonist reversibly inhibits
spermatogenesis. Given the importance of RARα in regulating spermatogenesis, we …

The importance of dietary retinol (vitamin A) and retinoid signaling for normal development
and differentiation has been recognised for many years. Vitamin A deficiency results in a …

Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts
in a hormone-like manner through binding to and activating three nuclear receptor isotypes …

Signaling through vitamin A metabolites is indispensable for spermatogenesis, and
disruption of retinoic acid receptor alpha (RARα) function resulted in male sterility and …

Retinoid X receptors (RXRs) are key regulators in retinoid signaling. Knowledge about the
effects of 9-cis-retinoic acid (9-cis-RA), the natural ligand for the RXRs, may also provide …

Elucidation of the retinoid signaling circuitry in the testis is critical to understanding how
male germ cells develop to spermatozoa. Retinoic acid receptor A protein (RARA) is an …

Spermatogenesis in mammals is a very complex, highly organized process, regulated in part
by testosterone and retinoic acid (RA). Much is known about how RA and testosterone …

As a first step in investigating the role of retinoic acid (RA) in mouse testis, we analyzed the
distribution pattern of the enzymes involved in vitamin A storage (lecithin: retinol …

Male animals are sterile due to testicular degeneration in the absence of retinoic acid (RA)
or functional retinoic acid receptor-α (RARα). This degeneration can be reversed by injecting …