Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Mitochondrial dysfunction has been associated with long-term toxicities of human
immunodeficiency virus (HIV) therapy, particularly with the nucleoside analog reverse …

The combined pharmacological approach to the treatment of HIV infection, known as highly
active antiretroviral therapy (HAART), has dramatically reduced AIDS-related morbidity and …

Nucleoside reverse transcriptase inhibitors (NRTIs) in combination with other antiretrovirals
(HAART) are critical in current AIDS therapy, but mitochondrial side effects have come to …

Antiretroviral therapy has dramatically reduced mortality in human immunodeficiency virus
(HIV) infection. In 1988, the suggestion that the first antiretroviral drug, zidovudine, was the …

Importance of the field: HIV/AIDS is a worldwide epidemic. While there remains no cure for
the HIV-1 infection, nucleoside reverse transcriptase inhibitors (NRTIs) have helped …

OBJECTIVES: This article reviews the clinical manifestations of mitochondrial toxicity
associated with the use of nucleoside analog reverse transcriptase inhibitors (NRTIs) and …

OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …

Objective To assess in vitro if uridine may be suitable to prevent or treat mitochondrial
toxicity related to nucleoside analogue reverse transcriptase inhibitors (NRTIs). Methods …

This review is intended to provide understanding of the function of mitochondria, the
advantages and disadvantages of available techniques for assessing mitochondrial function …