The promise of EPC-based therapies on vascular dysfunction in diabetes

A Georgescu, N Alexandru, A Constantinescu… - European journal of …, 2011 - Elsevier
Diabetes mellitus is one of the most common metabolic diseases in the world and the
vascular dysfunction represents a challenging clinical problem. In diabetes, endothelial cells …

[HTML][HTML] Vascular dysfunction in diabetes: The endothelial progenitor cells as new therapeutic strategy

A Georgescu - World journal of diabetes, 2011 - ncbi.nlm.nih.gov
The vascular endothelium is a critical determinant of diabetes-associated vascular
complications, and improving endothelial function is an important target for therapy …

The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells

V Altabas, J Marinković Radošević, L Špoljarec… - Biomedicines, 2023 - mdpi.com
Diabetes is one of the leading chronic diseases globally with a significant impact on
mortality. This condition is associated with chronic microvascular and macrovascular …

Dysfunction of endothelial progenitor cells under diabetic conditions and its underlying mechanisms

KA Kim, YJ Shin, JH Kim, H Lee, SY Noh… - Archives of pharmacal …, 2012 - Springer
Cardiovascular complications have been major concerns in the treatment of diabetes, and
up to 80% of all deaths in diabetic patients are linked to cardiovascular problems. Impaired …

Challenges in vascular repair by endothelial progenitor cells in diabetic patients

N António, R Fernandes… - … Current Drug Targets …, 2010 - ingentaconnect.com
Endothelial progenitor cells (EPCs) are a special type of stem cells, derived from bone
marrow that can be mobilized to the peripheral circulation in response to many stimuli. EPCs …

The promise of cell-based therapies for diabetic complications: challenges and solutions

YPR Jarajapu, MB Grant - Circulation research, 2010 - Am Heart Assoc
The discovery of endothelial progenitor cells (EPCs) in human peripheral blood advanced
the field of cell-based therapeutics for many pathological conditions. Despite the lack of …

Potential manipulation of endothelial progenitor cells in diabetes and its complications

GP Fadini, A Avogaro - Diabetes, Obesity and Metabolism, 2010 - Wiley Online Library
Diabetes mellitus increases cardiovascular risk through its negative impact on vascular
endothelium. Although glucotoxicity and lipotoxicity account for endothelial cell damage …

Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box?

A Liew, JH McDermott, F Barry… - Diabetes, Obesity and …, 2008 - Wiley Online Library
The discovery of endothelial progenitor cell (EPC) a decade ago has refuted the previous
belief that vasculogenesis only occurs during embryogenesis. The reduced circulating …

Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder

RK Ambasta, H Kohli, P Kumar - Journal of Translational Medicine, 2017 - Springer
Background Reduced levels of endothelial progenitor cells (EPCs) counts have been
reported in diabetic mellitus (DM) patients and other diabetes-related disorder. EPCs are a …

Modulating putative endothelial progenitor cells for the treatment of endothelial dysfunction and cardiovascular complications in diabetes

J Wils, J Favre, J Bellien - Pharmacology & therapeutics, 2017 - Elsevier
Diabetes induces a decrease in the number and function of different pro-angiogenic cell
types generically designated as putative endothelial progenitor cells (EPC), which …