DD K, a peptide first isolated from the skin secretion of the Phyllomedusa distincta frog, has
been prepared by solid-phase chemical peptide synthesis and its conformation was studied …

Acyl conjugation to antimicrobial peptides is known to enhance antimicrobial properties.
Here, we investigated the consequences of aminolauryl (NC 12) conjugation to the …

Linear peptide antibiotics have been isolated from amphibians, insects and humans and
used as templates to design cheaper and more potent analogues for medical applications …

The heterodimeric antimicrobial peptide distinctin is composed of 2 linear peptide chains of
22-and 25-aa residues that are connected by a single intermolecular SS bond. This …

Dermaseptins, small polycationic peptides synthesized by amphibians, exert a lytic action on
bacteria, protozoa, yeast, and filamentous fungi at micromolar concentrations, but unlike …

The mechanism of membrane interaction of two amphipathic antimicrobial peptides, MSI-78
and MSI-594, derived from magainin-2 and melittin, is presented. Both the peptides show …

Solid-state NMR spectroscopic techniques provide valuable information about the structure,
dynamics and topology of membrane-inserted polypeptides. In particular antimicrobial …

The antimicrobial peptide GL13K encompasses 13 amino acid residues and has been
designed and optimized from the salivary protein BPIFA2 to exhibit potent bacteriocidal and …

The membrane-disruptive antimicrobial peptide PGLa is found to change its orientation in a
dimyristoyl-phosphatidylcholine bilayer when its concentration is increased to biologically …

Protegrin-1 (PG-1) is a broad-spectrum β-sheet antimicrobial peptide found in porcine
leukocytes. The mechanism of action and the orientation of PG-1 in lipid bilayers are here …