The concept of multi-targeted immunotherapeutic systems has propelled the field of cancer
immunotherapy into an exciting new era. Multi-effector molecules can be designed to …

Uveal melanoma is a rare subtype of melanoma that once metastatic portends a poor
prognosis. Likely due to the distinct differences in biology, metastatic potential, and …

The dynamic expression of various phenotypic markers during B cell development not only
defines the particular stage in ontogeny but also provides the necessary growth …

Simple Summary Mature T-and NK-cell leukemia/lymphoma (MTCL/L) are a heterogeneous
group of rare, mostly poor prognostic neoplastic entities. In the past, immunotherapeutic …

Uveal melanoma is the most common primary intraocular tumor in adults. 1 Before the mid-
20th century, enucleation was the mainstay of treatment for uveal melanoma. Although this …

Despite the dramatic progress that has been made in elucidating the complex biology of
cancer and translating this knowledge into novel therapeutics, there remain malignancies for …

Introduction Uveal melanoma (UM) is the most common intraocular cancer and represents a
discrete subtype of melanoma. Metastatic disease, which occurs in half of patients, has a …

Many therapies are being developed that use the patient's own immune response to treat
malignancies. One of the new types of immunotherapy is the application of monoclonal …

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and
accounts for about 5% of all melanomas. Primary disease can be effectively controlled by …

Surgery remains the mainstay treatment for the majority of carcinomas and melanomas in
the periocular region, orbit, and conjunctiva. However, for patients with locally advanced or …