This paper reviews the functional brain imaging studies in depressed patients treated with
sleep deprivation. Sleep deprivation is an excellent experimental model of antidepressant …

The antidepressant and cerebral metabolic effects of total sleep deprivation (TSD) or partial
sleep deprivation (PSD) for one night has been studied with functional neuroimaging in …

The antidepressant properties of total sleep deprivation (TSD) have been well established.
There is some evidence that TSD may improve depression by altering central dopamine …

OBJECTIVE: Sleep deprivation has been shown to have an antidepressant benefit in a
subgroup of depressed patients. Functional imaging studies by the authors and others have …

One night of total or partial sleep deprivation (SD) produces temporary remissions in 40–
60% of patients with major depression. Two unmedicated patients with major depression …

Sleep deprivation has been shown to have a rapid, nonpharmacologic antidepressant effect
in studies involving over 1,500 patients (1–3). In normal subjects sleep deprivation is …

We studied 10 patients with melancholia before and after sleep deprivation and 8 controls
with Tc-99m-hexamethylpropylenamineoxime (HMPAO) single photon emission computed …

Single photon emission computed tomography (SPECT) with technetium-99m-d, 1-
hexamethyl-propylene amine oxime (99Tcm-HMPAO) was carried out in 20 melancholic …

This paper attempts to summarize the evidence for the hypothesis that psychostimulant-like
neurotransmitter processes within certain regions of the limbic system induce the positive …

The possible predictive value of regional cerebral perfusion patterns with respect to the
response to partial sleep deprivation (PSD) was evaluated in 15 major depressive patients …