Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry, and structural analysis

L Czech, L Hermann, N Stöveken, AA Richter… - Genes, 2018 - mdpi.com
Fluctuations in environmental osmolarity are ubiquitous stress factors in many natural
habitats of microorganisms, as they inevitably trigger osmotically instigated fluxes of water …

Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms

N Widderich, A Hoeppner, M Pittelkow, J Heider… - PloS one, 2014 - journals.plos.org
Ectoine and hydroxyectoine are well-recognized members of the compatible solutes and are
widely employed by microorganisms as osmostress protectants. The EctABC enzymes …

Ectoines in cell stress protection: uses and biotechnological production

JM Pastor, M Salvador, M Argandoña, V Bernal… - Biotechnology …, 2010 - Elsevier
Microorganisms produce and accumulate compatible solutes aiming at protecting
themselves from environmental stresses. Among them, the wide spread in nature ectoines …

Extremolytes: natural compounds from extremophiles for versatile applications

G Lentzen, T Schwarz - Applied microbiology and biotechnology, 2006 - Springer
Extremophilic microorganisms have adopted a variety of ingenious strategies for survival
under high or low temperature, extreme pressure, and drastic salt concentrations. A novel …

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase

J Bursy, AJ Pierik, N Pica, E Bremer - Journal of Biological Chemistry, 2007 - ASBMB
By using natural abundance 13 C NMR spectroscopy, we investigated the types of
compatible solutes synthesized in a variety of Bacilli under high salinity growth conditions …

Biosynthesis of the stress-protectant and chemical chaperon ectoine: biochemistry of the transaminase EctB

AA Richter, CN Mais, L Czech, K Geyer… - Frontiers in …, 2019 - frontiersin.org
Bacteria frequently adapt to high osmolarity surroundings through the accumulation of
compatible solutes. Ectoine is a prominent member of these types of stress protectants and …

Microbial production of ectoine and hydroxyectoine as high-value chemicals

M Liu, H Liu, M Shi, M Jiang, L Li, Y Zheng - Microbial Cell Factories, 2021 - Springer
Ectoine and hydroxyectoine as typical representatives of compatible solutes are not only
essential for extremophiles to survive in extreme environments, but also widely used in …

Strangers in the archaeal world: osmostress‐responsive biosynthesis of ectoine and hydroxyectoine by the marine thaumarchaeon Nitrosopumilus maritimus

N Widderich, L Czech, FJ Elling… - Environmental …, 2016 - Wiley Online Library
Ectoine and hydroxyectoine are compatible solutes widely synthesized by members of the
Bacteria to cope with high osmolarity surroundings. Inspection of 557 archaeal genomes …

Ectoine accumulation and osmotic regulation in Brevibacterium linens

T Bernard, M Jebbar, Y Rassouli… - …, 1993 - microbiologyresearch.org
Brevibacterium linens can grow in media of relatively high osmotic strength (up to 3 m-
NaCl). Optimal growth in minimal medium occurred with either added NaCl (0· 5–1 m) or …

Osmotic adaptation and compatible solute biosynthesis of phototrophic bacteria as revealed from genome analyses

JF Imhoff, T Rahn, S Künzel, A Keller, SC Neulinger - Microorganisms, 2020 - mdpi.com
Osmotic adaptation and accumulation of compatible solutes is a key process for life at high
osmotic pressure and elevated salt concentrations. Most important solutes that can protect …