Matrix metalloproteinases (MMPs) exert both pro-and antiangiogenic functions by the
release of cytokines or proteolytically generated angiogenic inhibitors from extracellular …

Matrix metalloproteinases (MMPs) are a family of enzymes that proteolytically degrade
various components of the extracellular matrix (ECM). Angiogenesis is the process of …

Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an
integral part of physiological processes such as embryonic development, the female …

Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of
disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and …

During pathologic vessel remodeling, vascular smooth muscle cells (VSMCs) embedded
within the collagen-rich matrix of the artery wall mobilize uncharacterized proteolytic systems …

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
primarily degrade components of the extracellular matrix (ECM). Remodeling of the ECM by …

Angiogenesis is facilitated by the proteolytic activities of members of the matrix
metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP directly regulate …

Processes such as cell proliferation, angiogenesis, apoptosis, or invasion are strongly
influenced by the surrounding microenvironment of the tumor. Therefore, the ability to …

Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth
factor (VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation …

Matrix metalloproteinases (MMPs), a specialized group of enzymes capable of
proteolytically degrading extracellular matrix proteins, have been postulated to play an …