Objective: Since it can be activated by oxidative stress, the TRP melastatin 2 (TRPM2)
channel has recently been established as a potential therapeutic target in the fight against …

Amaç: TRP melastatin 2 (TRPM2) kanalı oksidatif stres tarafından aktive edilebildiğinden
diyabet, inflamasyon, miyokard enfarktüsü gibi oksidatif strese bağlı hastalıklarla …

Although the NMDA receptor was identified to mediate excitotoxicity for ischemia-
reperfusion (IR) injury, its antagonists have not shown clinical efficacy. Unrelated to NMDA …

It has long been recognized that voltage-gated calcium and chemical channels influence the
Ca< sup> 2+ influx in neural cells. Transient receptor potential, or TRP, is a novel channel …

Cerebral ischemia-reperfusion injury triggers a deleterious process ending in neuronal
death. This process has two components, a glutamate-dependent and a glutamate …

Abstract Ischemia/reperfusion (I/R) injury is the main cause of tissue damage and
dysfunction. I/R injury is characterized by Ca 2+ overload and production of reactive oxygen …

OBJECTIVE: Mammalian transient receptor potential melastatin (TRPM) channels are a form
of calcium channels and they transport calcium and magnesium ions. TRPM has eight …

There is very little work on the expression of TRPM6/7 in ischemia reperfusion models. In
previous studies, after ischemia, reperfusion had been kept limited to 24 h, yet in our study …

Methods SH-SY5Y cells were subjected to oxygen-glucose deprivation/reperfusion (OGD/R)
to mimic cerebral I/R injury in vitro. Cell morphology, viability and apoptosis were detected …

Stroke is one of the major causes of mortality and morbidity worldwide, yet novel therapeutic
treatments for this condition are lacking. This review focuses on the roles of the transient …