BAX and BAK are proapoptotic members of the BCL2 family that directly mediate
mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis …

Apotosis is an essential process tightly regulated by the Bcl-2 protein family where
proapoptotic Bax triggers cell death by perforating the mitochondrial outer membrane …

BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial
outer membrane permeabilization. However, the mechanism by which they assemble the …

Mitochondria are crucial compartments of eukaryotic cells because they function as the
cellular power plant and play a central role in the early stages of programmed cell death …

BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose
molecular mechanism of action remains to be fully dissected in intact cells, mainly due to the …

Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of
apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial …

Permeabilization of the outer mitochondrial membrane by pore‐forming Bcl2 proteins is a
crucial step for the induction of apoptosis. Despite a large set of data suggesting global …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

Bcl-2 proteins are key regulators of the mitochondrial outer membrane (MOM)
permeabilization that mediates apoptosis. During apoptosis, Bid is cleaved (cBid) and …

During apoptosis, pro-apoptotic BAX and BAK are activated, causing mitochondrial outer
membrane permeabilisation (MOMP), caspase activation and cell death. However, even in …