Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

MJ Shurtleff, J Yao, Y Qin… - Proceedings of the …, 2017 - National Acad Sciences
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …

Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes

OA Kossinova, AV Gopanenko, SN Tamkovich… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Exosomes, membranous vesicles secreted by various cells, are involved in intercellular
communication and carry vast repertoires of RNAs and proteins. Processes mediating RNA …

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

MJ Shurtleff, MM Temoche-Diaz, KV Karfilis, S Ri… - elife, 2016 - elifesciences.org
Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …

[HTML][HTML] Reassessment of exosome composition

DK Jeppesen, AM Fenix, JL Franklin, JN Higginbotham… - Cell, 2019 - cell.com
The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular
matter have led to debate about contents and functional properties of exosomes. Here, we …

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

AO Batagov, IV Kurochkin - Biology direct, 2013 - Springer
Small secreted membrane vesicles called exosomes have recently attracted a great interest
after the discovery that they transfer mRNA that can be translated into protein in recipient …

Isolation and characterization of RNA-containing exosomes

C Lässer, M Eldh, J Lötvall - JoVE (Journal of Visualized Experiments), 2012 - jove.com
The field of exosome research is rapidly expanding, with a dramatic increase in publications
in recent years. These small vesicles (30-100 nm) of endocytic origin were first proposed to …

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

C Villarroya-Beltri, C Gutiérrez-Vázquez… - Nature …, 2013 - nature.com
Exosomes are released by most cells to the extracellular environment and are involved in
cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs …

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

L Statello, M Maugeri, E Garre, M Nawaz, J Wahlgren… - PloS one, 2018 - journals.plos.org
The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA);
however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely …

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

XM Liu, L Ma, R Schekman - Elife, 2021 - elifesciences.org
Exosomes may mediate cell-to-cell communication by transporting various proteins and
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

H Sork, G Corso, K Krjutskov, HJ Johansson… - Scientific reports, 2018 - nature.com
Extracellular vesicles (EVs) mediate cell-to-cell communication by delivering or displaying
macromolecules to their recipient cells. While certain broad-spectrum EV effects reflect their …