Complement, a target for therapy in inflammatory and degenerative diseases

BP Morgan, CL Harris - Nature reviews Drug discovery, 2015 - nature.com
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …

Expanding horizons in complement drug discovery: challenges and emerging strategies

CL Harris - Seminars in immunopathology, 2018 - Springer
The complement system is best known for its role in innate immunity, providing a first line of
defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and …

Progress and trends in complement therapeutics

D Ricklin, JD Lambris - Complement Therapeutics, 2013 - Springer
The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …

Complement: A primer for the coming therapeutic revolution

SR Barnum - Pharmacology & therapeutics, 2017 - Elsevier
The complement system is an important part of the innate and adaptive immune systems.
Originally characterized as a single serum component contributing to the killing of bacteria …

Tipping the balance: intricate roles of the complement system in disease and therapy

RB Pouw, D Ricklin - Seminars in Immunopathology, 2021 - Springer
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …

[HTML][HTML] Developments in anti-complement therapy; from disease to clinical trial

CL Harris, RB Pouw, D Kavanagh, R Sun… - Molecular immunology, 2018 - Elsevier
The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

New milestones ahead in complement-targeted therapy

D Ricklin, JD Lambris - Seminars in immunology, 2016 - Elsevier
The complement system is a powerful effector arm of innate immunity that typically confers
protection from microbial intruders and accumulating debris. In many clinical situations …

[HTML][HTML] Compendium of current complement therapeutics

WM Zelek, L Xie, BP Morgan, CL Harris - Molecular immunology, 2019 - Elsevier
The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Complement therapeutics; history and current progress

BP Morgan, CL Harris - Molecular immunology, 2003 - Elsevier
Complement (C) performs vital roles in immune surveillance, from killing of bacteria to
generation of an optimal antibody response. However, the mediators responsible for this …

[HTML][HTML] Complement in therapy and disease: regulating the complement system with antibody-based therapeutics

JPM Melis, K Strumane, SR Ruuls, FJ Beurskens… - Molecular …, 2015 - Elsevier
Complement is recognized as a key player in a wide range of normal as well as disease-
related immune, developmental and homeostatic processes. Knowledge of complement …