Complement, a target for therapy in inflammatory and degenerative diseases
BP Morgan, CL Harris - Nature reviews Drug discovery, 2015 - nature.com
The complement system is a key innate immune defence against infection and an important
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
driver of inflammation; however, these very properties can also cause harm. Inappropriate or …
Expanding horizons in complement drug discovery: challenges and emerging strategies
CL Harris - Seminars in immunopathology, 2018 - Springer
The complement system is best known for its role in innate immunity, providing a first line of
defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and …
defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and …
Progress and trends in complement therapeutics
D Ricklin, JD Lambris - Complement Therapeutics, 2013 - Springer
The past few years have proven to be a highly successful and exciting period for the field of
complement-directed drug discovery and development. Driven by promising experiences …
complement-directed drug discovery and development. Driven by promising experiences …
Complement: A primer for the coming therapeutic revolution
SR Barnum - Pharmacology & therapeutics, 2017 - Elsevier
The complement system is an important part of the innate and adaptive immune systems.
Originally characterized as a single serum component contributing to the killing of bacteria …
Originally characterized as a single serum component contributing to the killing of bacteria …
Tipping the balance: intricate roles of the complement system in disease and therapy
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
[HTML][HTML] Developments in anti-complement therapy; from disease to clinical trial
The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …
tissue homeostasis, providing a first line of defence against infection and playing a key role …
New milestones ahead in complement-targeted therapy
D Ricklin, JD Lambris - Seminars in immunology, 2016 - Elsevier
The complement system is a powerful effector arm of innate immunity that typically confers
protection from microbial intruders and accumulating debris. In many clinical situations …
protection from microbial intruders and accumulating debris. In many clinical situations …
[HTML][HTML] Compendium of current complement therapeutics
WM Zelek, L Xie, BP Morgan, CL Harris - Molecular immunology, 2019 - Elsevier
The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …
tissue homeostasis, providing a first line of defence against infection and playing a key role …
Complement therapeutics; history and current progress
BP Morgan, CL Harris - Molecular immunology, 2003 - Elsevier
Complement (C) performs vital roles in immune surveillance, from killing of bacteria to
generation of an optimal antibody response. However, the mediators responsible for this …
generation of an optimal antibody response. However, the mediators responsible for this …
[HTML][HTML] Complement in therapy and disease: regulating the complement system with antibody-based therapeutics
JPM Melis, K Strumane, SR Ruuls, FJ Beurskens… - Molecular …, 2015 - Elsevier
Complement is recognized as a key player in a wide range of normal as well as disease-
related immune, developmental and homeostatic processes. Knowledge of complement …
related immune, developmental and homeostatic processes. Knowledge of complement …