[HTML][HTML] Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age

S Bhattacharya, T Holowka, EP Orner, BC Fries - Scientific reports, 2019 - nature.com
Candida auris is an emerging multi-drug resistant yeast that causes systemic infections.
Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric …

Experimental evolution identifies adaptive aneuploidy as a mechanism of fluconazole resistance in Candida auris

J Bing, T Hu, Q Zheng, JF Muñoz… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Candida auris is a newly emerging fungal pathogen of humans and has attracted
considerable attention from both the clinical and basic research communities. Clinical …

Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

SH Kim, KR Iyer, L Pardeshi, JF Muñoz, N Robbins… - MBio, 2019 - Am Soc Microbiol
Candida auris is an emerging fungal pathogen and a serious global health threat as the
majority of clinical isolates display elevated resistance to currently available antifungal …

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

LS Burrack, RT Todd, N Soisangwan, NP Wiederhold… - MBio, 2022 - Am Soc Microbiol
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the
human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin …

Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance

H Carolus, S Pierson, JF Muñoz, A Subotić, RB Cruz… - MBio, 2021 - Am Soc Microbiol
Candida auris is globally recognized as an opportunistic fungal pathogen of high concern,
due to its extensive multidrug resistance (MDR). Still, molecular mechanisms of MDR are …

A zinc cluster transcription factor contributes to the intrinsic fluconazole resistance of Candida auris

EM Mayr, B Ramírez-Zavala, I Krüger, J Morschhäuser - Msphere, 2020 - Am Soc Microbiol
The recently emerged pathogenic yeast Candida auris is a major concern for human health,
because it is easily transmissible, difficult to eradicate from hospitals, and highly drug …

Deciphering the Mrr1/Mdr1 pathway in azole resistance of Candida auris

J Li, AT Coste, D Bachmann, D Sanglard… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Candida auris is an emerging yeast pathogen with a remarkable ability to develop antifungal
resistance, in particular to fluconazole and other azoles. Azole resistance in C. auris was …

Upc2-mediated mechanisms of azole resistance in Candida auris

J Li, L Aubry, D Brandalise, AT Coste… - Microbiology …, 2024 - Am Soc Microbiol
Candida auris is an emerging yeast pathogen of major concern because of its ability to
cause hospital outbreaks of invasive candidiasis and to develop resistance to antifungal …

[HTML][HTML] Candida auris Genetics and Emergence

A Chowdhary, K Jain, N Chauhan - Annual Review of …, 2023 - annualreviews.org
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to
global human health. Since the first reported case in 2009 in Japan, C. auris infections have …

Directed evolution detects supernumerary centric chromosomes conferring resistance to azoles in Candida auris

A Narayanan, P Kumar, A Chauhan, M Kumar, K Yadav… - MBio, 2022 - Am Soc Microbiol
Candida auris exhibits resistance to multiple antifungal drug classes and sterilization
agents, posing threats to the immunocompromised worldwide. Among the four major …