In recent years, a number of novel tandem mass spectrometry approaches utilizing radical‐
driven peptide gas‐phase fragmentation chemistry have been developed. These …

The present study demonstrates that one-step peptide backbone fragmentations can be
achieved using the TEMPO [2-(2, 2, 6, 6-tetramethyl piperidine-1-oxyl)]-assisted free radical …

Free radical-initiated peptide sequencing (FRIPS) mass spectrometry derives advantage
from the introduction of highly selective low-energy dissociation pathways in target peptides …

We have synthesized a homobifunctional active ester cross‐linking reagent containing a
TEMPO (2, 2, 6, 6‐tetramethylpiperidine‐1‐oxy) moiety connected to a benzyl group (Bz) …

Peptide dissociation behavior in TEMPO (2, 2, 6, 6-tetramethylpiperidine-1-oxyl)-based
FRIPS (free radical initiated peptide sequencing) mass spectrometry was analyzed in both …

The gas‐phase free radical initiated peptide sequencing (FRIPS) fragmentation behavior of
o‐TEMPO‐Bz‐conjugated peptides with an intra‐and intermolecular disulfide bond was …

Protein identification is routinely accomplished by peptide sequencing using mass
spectrometry (MS) after enzymatic digestion. Site-specific chemical modification may …

We implemented negative electron-transfer dissociation (NETD) on a hybrid ion
trap/Orbitrap mass spectrometer to conduct ion/ion reactions using peptide anions and …

The recent development of novel fragmentation processes based on either electron capture
directly or transfer from an anion show great potential for solving problems in proteomics that …

N-terminal peptide derivatization strategies used in conjunction with tandem mass
spectrometry to yield simplified fragmentation patterns have shown limited success for the …