The mechanism by which tolerance is induced via systemic administration of high doses of
aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific …

Antigen-specific human T cell clones specific for defined peptides of influenza A
hemagglutinin were found to be rendered unresponsive by incubation with moderately high …

Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell
receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal …

Effector cells that demonstrate delayed‐type hypersensitivity (DTH) on transfer with antigen
to naive mice can he recovered from the lungs of mice inoculated intranasally 6 days earlier …

The induction of T-cell responses involves the recognition of extrinsic antigen in association
with antigens of the major histocompatibility complex (MHC), in mice and man, with different …

The role of the medullary thymic epithelial cells in tolerance induction to MHC class I
restricted self peptides has been analyzed by studying the beta-galactosidase (beta-gal) …

Establishment of antigen-specific tolerance among mature T cells has been a long debated,
yet poorly understood issue. In this study we have used transgenic mice bearing a class II …

We have evaluated the ability of ovalbumin to induce T-cell-specific tolerance in SJL mice. A
significant decrease of interleukin 2 in lymph-node culture supernatants from tolerant mice …

Daily gastric intubation of lipopolysaccharide (LPS)-responsive C3H/HeN, BALB/c, and
Swiss mice with SRBC for 2 wk resulted in oral tolerance, whereas similarly treated LPS …

Intranasal exposure of athymic (nu/nu) BALB/c mice to influenza virus leads to a persistent
infection of the respiratory tract from which the mice die, usually within 3 to 4 wk with …