Susceptibility to ankylosing spondylitis is highly genetic, with a heritability greater than 90%.
Presence of the HLA-B27 MHC class I allele remains the greatest genetic risk factor …

Understanding how HLA-B27 contributes to the pathogenesis of spondyloarthritis continues
to be an important goal. Current efforts are aimed largely on three areas of investigation; …

The mechanism by which the MHC class I allele, HLA-B27, contributes to spondyloarthritis
pathogenesis is unknown. In contrast to other alleles that have been examined, HLA-B27 …

Objective HLA–B27 is implicated in the pathogenesis of spondylarthritis (SpA), yet the
molecular mechanisms are incompletely defined. HLA–B27 misfolding has been associated …

HLA‑B27 plays a central role in the pathogenesis of many spondyloarthropathies and in
particular ankylosing spondylitis. The observation that the HLA‑B27 heavy chain has a …

Objective. HLA-B27 positivity strongly influences the susceptibility to and phenotype of
spondyloarthropathies (SpA). This study was designed to screen factors that activate the …

In the thirty years since the initial discovery of a striking association between HLA-B27 and
susceptibility to ankylosing spondylitis, numerous hypotheses have been proposed to …

HLA-B27 is the strongest genetic risk factor for ankylosing spondylitis (AS), but how it
contributes to AS remains unknown. Increased endoplasmic reticulum stress, triggered by …

More than three decades after the discovery of HLA-B27 as a major genetic clue to the
origins of ankylosing spondylitis, much has been learned about pathogenesis. However, the …

Objective HLA–B27 forms misfolded heavy chain dimers, which may predispose individuals
to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded …