Microglia have crucial roles in sculpting synapses and maintaining neural circuits during
development. To test the hypothesis that microglia continue to regulate neural circuit …

Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …

Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal
support, and immune defense of the brain parenchyma. Recently, the role played by …

Investigations on the role of microglia in the brain have traditionally been focused on their
contributions to disease states. However, recent observations have now convincingly shown …

Microglia actively survey the brain microenvironment and play essential roles in sculpting
synaptic connections during brain development. While microglial functions in the adult brain …

Microglia are the primary innate immune cells in the CNS. Since their initial discovery and
characterization, decades of research have revealed their unique roles not only in …

Neurogenesis is altered in neurodegenerative disorders, partly regulated by inflammatory
factors. We have investigated whether microglia, the innate immune brain cells, regulate …

Microglia are enigmatic non-neuronal cells that infiltrate and take up residence in the brain
during development and are thought to perform a surveillance function. An established …

Highlights•Recent GWAS identified microglia-related pathways as risk factors for
Alzheimer's.•Role of immune molecules in synapse loss, a hallmark of Alzheimer's, is poorly …

Highlights•Microglial cytokine signaling regulates axon outgrowth and synaptogenesis.•
CX3CR1 regulates microglial recruitment to synapses necessary for synaptic …