It took almost 100 years before a meaningful advance occurred in any basic science
understanding of Parkinson disease (PD) following James Parkinson's description in 1817 …

Though primarily a sporadic condition, Parkinson's disease is increasingly recognized to be
a multifactorial disease with a strong genetic component. At a cellular level, disruptions of …

There has been significant progress in our knowledge of the cause, the pathogenesis, and
the nature of the mechanism of cell death in Parkinson's disease (PD). Mutations in single …

Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

Parkinson's disease, together with the other two major agerelated neurodegenerative
diseases Alzheimer's disease and amyotrophic lateral sclerosis, impose a huge economic …

Parkinson's disease (PD) is the second most common neurodegenerative disease,
manifesting as a characteristic movement disorder with a number of additional non-motor …

Important advances in Parkinson disease (PD) in 2015 included a revision of its clinical
diagnostic criteria and a proposal for research criteria defining prodromal PD. Research …

Parkinson's disease (PD) is a chronic, disabling neurodegenerative proteinopathy
characterized by degeneration of the dopaminergic nigrostriatal system, involvement of …

PURPOSE OF REVIEW Parkinson disease is a common neurodegenerative disorder that
affects millions of people worldwide. Important advances in the treatment, etiology, and the …

The pathological features that characterize idiopathic Parkinson's disease have been
recognized since the beginning of the last century. Important recent advances include the …