Heme degradation and vascular injury
Heme is an essential molecule in aerobic organisms. Heme consists of protoporphyrin IX
and a ferrous (Fe2+) iron atom, which has high affinity for oxygen (O2). Hemoglobin, the …
and a ferrous (Fe2+) iron atom, which has high affinity for oxygen (O2). Hemoglobin, the …
Heme and the vasculature: an oxidative hazard that induces antioxidant defenses in the endothelium
Heme proteins transport oxygen and facilitate redox reactions. Heme, however, may be
dangerous, especially when free in biologic systems. For example, iron released from …
dangerous, especially when free in biologic systems. For example, iron released from …
Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment
Iron-derived reactive oxygen species are involved in the pathogenesis of numerous vascular
disorders. One abundant source of redox active iron is heme, which is inherently dangerous …
disorders. One abundant source of redox active iron is heme, which is inherently dangerous …
Oxidative pathways in the sickle cell and beyond
AI Alayash - Blood Cells, Molecules, and Diseases, 2018 - Elsevier
Polymerization of deoxy sickle cell hemoglobin (HbS) is well recognized as the primary
event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs) …
event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs) …
Haem, haem oxygenase and ferritin in vascular endothelial cell injury
J Balla, GM Vercellotti, K Nath, A Yachie… - Nephrology Dialysis …, 2003 - academic.oup.com
Iron-derived reactive oxygen species (ROS) are implicated in the pathogenesis of numerous
vascular disorders including atherosclerosis, microangiopathic haemolytic anaemia …
vascular disorders including atherosclerosis, microangiopathic haemolytic anaemia …
Heme, heme oxygenase and ferritin in vascular endothelial cell injury
Iron‐derived reactive oxygen species are implicated in the pathogenesis of numerous
vascular disorders including atherosclerosis, microangiopathic hemolytic anemia, vasculitis …
vascular disorders including atherosclerosis, microangiopathic hemolytic anemia, vasculitis …
Different faces of the heme-heme oxygenase system in inflammation
FA Wagener, HD Volk, D Willis, NG Abraham… - Pharmacological …, 2003 - ASPET
The heme-heme oxygenase system has recently been recognized to possess important
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …
Heme degradation by reactive oxygen species
E Nagababu, JM Rifkind - Antioxidants & redox signaling, 2004 - liebertpub.com
Heme proteins play a major role in various biological functions, such as oxygen sensing,
electron transport, signal transduction, and antioxidant defense enzymes. Most of these …
electron transport, signal transduction, and antioxidant defense enzymes. Most of these …
Reactive species in sickle cell disease
M Aslan, D THORNLEY‐BROWN… - Annals of the New …, 2000 - Wiley Online Library
The red cell is a relatively abundant locus of both free radical generation and reaction.
Erythrocytes have a high content of unsaturated membrane lipids, a rich oxygen supply and …
Erythrocytes have a high content of unsaturated membrane lipids, a rich oxygen supply and …
Heme, heme oxygenase, and endoplasmic reticulum stress—a new insight into the pathophysiology of vascular diseases
The prevalence of vascular disorders continues to rise worldwide. Parallel with that, new
pathophysiological pathways have been discovered, providing possible remedies for …
pathophysiological pathways have been discovered, providing possible remedies for …