Since the early 1990s, several strains of genetically modified mice have been developed as
models for experimental atherosclerosis. Among the available models, the apolipoprotein E …

Mice lacking ApoE (Apoe–/–) develop initially hypercholesterolemia and latterly
atherosclerosis. This study examined hemodynamics and endothelial function in 6-week-old …

Atherosclerosis is a multifactorial, long-lasting process in humans. Accordingly, animal
models in which more rapid changes occur can be useful for the study of this process …

Apolipoprotein (apo) E is a ligand for the receptor-mediated uptake of lipoprotein remnant
particles. Complete absence of apo E in humans leads to a severe form of type III …

Wild-type C57BL mice are known to be susceptible to diet-induced atherosclerosis, whilst
C3H mice are resistant. We investigated the effect of these background strains on the …

Arguably the most critical advancement in the elucidation of factors affecting atherogenesis
has been the development of mouse models of atherosclerosis. Among available models …

Cardiovascular diseases are presently the leading causes of morbidity and mortality in
Western societies, and early in the next millennium they are expected to become the main …

We examined the vascular structure and endothelium-dependent relaxation in two genetic
models of hypercholesterolemia: apolipoprotein E (apoE)-knockout mice and combined …

Given the multiple differences between mice and men, it was once thought that mice could
not be used to model atherosclerosis, principally a human disease. Apolipoprotein E …

Miniature pigs have advantages over rodents in modeling atherosclerosis because their
cardiovascular system and physiology are similar to that of humans. Apolipoprotein E …