In the context of stroke and revascularization therapy, brain ischemia-reperfusion injury is a
significant challenge that leads to oxidative stress and inflammation. Central to the cell's …

Cerebral ischemia-reperfusion injury is related to inflammation driven by free mitochondrial
DNA. At the same time, the pro-inflammatory activation of macrophages, that is, polarization …

Traumatic brain injury and aneurysmal subarachnoid haemorrhage are a major cause of
morbidity and mortality worldwide. Treatment options remain limited and are hampered by …

Background: The transfer of mitochondria from healthy mesenchymal stem cells (MSCs) to
injured MSCs has been shown to have potential therapeutic benefits for neural cell post …

We hypothesize that enhancing mitochondrial base excision repair (BER) capability in brain
will reduce reperfusion-associated ischemic brain injury. Post-stroke reperfusion was …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions
on entering adjacent cells. We recently demonstrated that these released Mts could enter …

Patients with acute ischemic stroke (AIS) suffer from infections associated with mortality. The
relevance of the innate immune system, and monocytes in particular, has emerged as an …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

Ischemic stroke is one of the major causes of morbidity and mortality worldwide.
Mitochondria play a vital role in the pathological processes of cerebral ischemic injury, but …