Plasma metabolomics and lipidomics differentiate obese individuals by peripheral neuropathy status

K Guo, MG Savelieff, AE Rumora… - The Journal of …, 2022 - academic.oup.com
Context Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D)
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …

[HTML][HTML] Candidate metabolite markers of peripheral neuropathy in Chinese patients with type 2 diabetes

MM Shao, HJ Xiang, H Lu, PH Yin, GW Li… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Objectives: To analyze the serum and urine metabolites present in type 2 diabetes mellitus
(T2DM) patients and T2DM patients with diabetic peripheral neuropathy (DPN) and to select …

Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes

AE Rumora, K Guo, FM Alakwaa… - Annals of clinical …, 2021 - Wiley Online Library
Objective The global rise in type 2 diabetes is associated with a concomitant increase in
diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes …

Association between metabolic syndrome components and polyneuropathy in an obese population

BC Callaghan, R Xia, E Reynolds, M Banerjee… - JAMA …, 2016 - jamanetwork.com
Importance Past studies have shown an association between metabolic syndrome and
polyneuropathy, but the precise components that drive this association remain unclear …

General and abdominal obesity and incident distal sensorimotor polyneuropathy: insights into inflammatory biomarkers as potential mediators in the KORA F4/FF4 …

S Schlesinger, C Herder, JM Kannenberg… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE To investigate the associations between different anthropometric
measurements and development of distal sensorimotor polyneuropathy (DSPN) considering …

Altered plasma amino acids and lipids associated with abnormal glucose metabolism and insulin resistance in older adults

RD Semba, M Gonzalez-Freire… - The Journal of …, 2018 - academic.oup.com
Abstract Context and Objectives Glucose metabolism becomes progressively impaired with
older age. Fasting glucose and insulin resistance are risk factors for premature death and …

Diabetes and obesity are the main metabolic drivers of peripheral neuropathy

BC Callaghan, LL Gao, Y Li, X Zhou… - Annals of clinical …, 2018 - Wiley Online Library
Objective To determine the associations between individual metabolic syndrome (MetS)
components and peripheral neuropathy in a large population‐based cohort from Pinggu …

Metabolic profiling of obesity with and without the metabolic syndrome: A multisample evaluation

L Lind, S Salihovic, J Sundström… - The Journal of …, 2022 - academic.oup.com
Context There is a dispute whether obesity without major metabolic derangements may
represent a benign condition or not. Objective We aimed to compare the plasma …

A high-fat diet disrupts nerve lipids and mitochondrial function in murine models of neuropathy

AE Rumora, K Guo, LM Hinder, PD O'Brien… - Frontiers in …, 2022 - frontiersin.org
As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase
worldwide, accompanying complications are also on the rise. The most prevalent …

Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes

F Afshinnia, EL Reynolds… - Annals of Clinical …, 2022 - Wiley Online Library
Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …