Plasma metabolomics and lipidomics differentiate obese individuals by peripheral neuropathy status
K Guo, MG Savelieff, AE Rumora… - The Journal of …, 2022 - academic.oup.com
Context Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D)
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …
[HTML][HTML] Candidate metabolite markers of peripheral neuropathy in Chinese patients with type 2 diabetes
MM Shao, HJ Xiang, H Lu, PH Yin, GW Li… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Objectives: To analyze the serum and urine metabolites present in type 2 diabetes mellitus
(T2DM) patients and T2DM patients with diabetic peripheral neuropathy (DPN) and to select …
(T2DM) patients and T2DM patients with diabetic peripheral neuropathy (DPN) and to select …
Plasma lipid metabolites associate with diabetic polyneuropathy in a cohort with type 2 diabetes
AE Rumora, K Guo, FM Alakwaa… - Annals of clinical …, 2021 - Wiley Online Library
Objective The global rise in type 2 diabetes is associated with a concomitant increase in
diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes …
diabetic complications. Diabetic polyneuropathy is the most frequent type 2 diabetes …
Association between metabolic syndrome components and polyneuropathy in an obese population
Importance Past studies have shown an association between metabolic syndrome and
polyneuropathy, but the precise components that drive this association remain unclear …
polyneuropathy, but the precise components that drive this association remain unclear …
General and abdominal obesity and incident distal sensorimotor polyneuropathy: insights into inflammatory biomarkers as potential mediators in the KORA F4/FF4 …
S Schlesinger, C Herder, JM Kannenberg… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE To investigate the associations between different anthropometric
measurements and development of distal sensorimotor polyneuropathy (DSPN) considering …
measurements and development of distal sensorimotor polyneuropathy (DSPN) considering …
Altered plasma amino acids and lipids associated with abnormal glucose metabolism and insulin resistance in older adults
RD Semba, M Gonzalez-Freire… - The Journal of …, 2018 - academic.oup.com
Abstract Context and Objectives Glucose metabolism becomes progressively impaired with
older age. Fasting glucose and insulin resistance are risk factors for premature death and …
older age. Fasting glucose and insulin resistance are risk factors for premature death and …
Diabetes and obesity are the main metabolic drivers of peripheral neuropathy
BC Callaghan, LL Gao, Y Li, X Zhou… - Annals of clinical …, 2018 - Wiley Online Library
Objective To determine the associations between individual metabolic syndrome (MetS)
components and peripheral neuropathy in a large population‐based cohort from Pinggu …
components and peripheral neuropathy in a large population‐based cohort from Pinggu …
Metabolic profiling of obesity with and without the metabolic syndrome: A multisample evaluation
L Lind, S Salihovic, J Sundström… - The Journal of …, 2022 - academic.oup.com
Context There is a dispute whether obesity without major metabolic derangements may
represent a benign condition or not. Objective We aimed to compare the plasma …
represent a benign condition or not. Objective We aimed to compare the plasma …
A high-fat diet disrupts nerve lipids and mitochondrial function in murine models of neuropathy
AE Rumora, K Guo, LM Hinder, PD O'Brien… - Frontiers in …, 2022 - frontiersin.org
As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase
worldwide, accompanying complications are also on the rise. The most prevalent …
worldwide, accompanying complications are also on the rise. The most prevalent …
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes
F Afshinnia, EL Reynolds… - Annals of Clinical …, 2022 - Wiley Online Library
Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …