Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …

Modified biomaterials have for years been the focus of research into establishing new bone
substitutes. In our preceding in vitro study employing different cell cultures, we developed …

Bone defects resulting from congenital anomalies, trauma, metabolic diseases, infections,
and tumor removal are formidable clinical challenges for orthopedics and craniofacial …

Accelerating the healing of bone fractures by local delivery of growth factors possessing
osteoinductive activity has been extensively demonstrated. Unfortunately, for some complex …

The inability to deliver bioactive agents locally in a transient but sustained manner is one of
the challenges on the development of bio-functionalized scaffolds for tissue engineering …

The management of large segmental bone defects caused by trauma or disease remains
clinically challenging within orthopaedics. The major impediment to bone healing with …

An ideal bone tissue engineering graft should have both excellent pro-osteogenesis and pro-
angiogenesis to rapidly realize the bone regeneration in vivo. To meet this goal, 2-N, 6-O …

The revascularization of grafted tissues is a complicated and non-straightforward process,
which makes it challenging to perform reconstructive surgery for critical-sized bone defects …

Large segmental bone defect repair remains a clinical and scientific challenge with
increasing interest focused on combining gene transfer with tissue engineering techniques …

Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …