Progenitor cells within a clonal population show variable proclivity toward lineage
commitment and differentiation. This cell-to-cell variability has been attributed to …

Background The balance between maintenance of the stem cell state and terminal
differentiation is influenced by the cellular environment. The switching between these states …

Variability of gene expression due to stochasticity of transcription or variation of extrinsic
signals, termed biological noise, is a potential driving force of cellular differentiation. While …

The lack of understanding of stem cell differentiation and proliferation is a fundamental
problem in developmental biology. Although gene regulatory networks (GRNs) for stem cell …

Autoregulation of transcription factors and cross-antagonism between lineage-specific
transcription factors are a recurrent theme in cell differentiation. An equally prevalent event …

Bistable regulatory elements enhance heterogeneity in cell populations and, in multicellular
organisms, allow cells to specialize and specify their fate. Our study demonstrates that in a …

Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these …

To protect against diverse challenges, the immune system must continuously generate an
arsenal of specialized cell types, each of which can mount a myriad of effector responses …

In some recent studies, a view emerged that stochastic dynamics governing the switching of
cells from one differentiation state to another could be characterized by a peak in gene …

Hematopoietic stem cell lineage choices are decided by genetic networks that are turned
ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at …