Importance Immunoglobulin G autoantibodies for aquaporin 4 (AQP4-IgG) serve as
diagnostic biomarkers for neuromyelitis optica spectrum disorder (NMOSD), and the most …

Objective Determine the utility of aquaporin 4 IgG (AQP4-IgG) testing (live cell-based assay)
for Neuromyelitis Optica Spectrum Disorders (NMOSD). Methods We included Mayo Clinic …

Background and Purpose The detection of aquaporin 4-IgG (AQP4-IgG) is now a critical
diagnostic criterion for neuromyelitis optica spectrum disorder (NMOSD). To evaluate the …

Background The presence of antibodies to aquaporin-4 (AQP4) has been identified as a key
characteristic of neuromyelitis optica spectrum disorder (NMOSD), an autoimmune …

Objective: To 1) determine, using contemporary recombinant antigen–based assays, the
aquaporin-4 (AQP4)–immunoglobulin G (IgG) detection rate in sequential sera of patients …

Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune
condition that is associated with severe disability. Approximately 40% of individuals are …

Background: Aquaporin 4-immunoglobulin G (AQP4-IgG) plays a major role in the
pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). Seropositive status for …

Background The aquaporin-4 antibody (AQP4-Ab) is a disease-specific autoantibody to
neuromyelitis optica (NMO). We aimed to evaluate the accuracy of the FACS assay in …

Objective: To compare performance of contemporary aquaporin-4–immunoglobulin (Ig) G
assays in clinical service. Methods: Sera from neurologic patients (4 groups) and controls …

Background Neuromyelitis optica spectrum disorders (NMOSD) are severe central nervous
system inflammatory demyelinating disorders (CNS IDD) characterized by monophasic or …