Comparative efficacy of antiepileptic drugs in children and adolescents: a network meta‐analysis
A Rosati, L Ilvento, E Lucenteforte, A Pugi… - …, 2018 - Wiley Online Library
Objective To estimate the comparative efficacy among antiepileptic drugs in the pediatric
population (0‐18 years). Methods Using the Embase and MEDLINE databases, we updated …
population (0‐18 years). Methods Using the Embase and MEDLINE databases, we updated …
Considerations for determining the efficacy of new antiseizure medications in children age 1 month to younger than 2 years
Objectives Drug treatment for children with epilepsy should, ideally, be governed by
evidence from adequate and well‐controlled clinical studies. However, these studies are …
evidence from adequate and well‐controlled clinical studies. However, these studies are …
Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data
Objectives To compare the time to treatment failure, remission and first seizure of 12 AEDs
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …
Meta-analyses of newer antiepileptic drugs as adjunct for treatment of focal epilepsy in children
NA Mohd-Tahir, SC Li - Epilepsy research, 2018 - Elsevier
Aim This study conducted a systematic review evaluating the effectiveness of newer
antiepileptic drugs (AEDs)(namely, lamotrigine, levetiracetam, topiramate, vigabatrin …
antiepileptic drugs (AEDs)(namely, lamotrigine, levetiracetam, topiramate, vigabatrin …
Efficacy of antiepileptic drugs in adults predicts efficacy in children: a systematic review
JM Pellock, WJ Carman, V Thyagarajan, T Daniels… - Neurology, 2012 - AAN Enterprises
Objective: Due to the challenges inherent in performing clinical trials in children, a
systematic review of published clinical trials was performed to determine whether the …
systematic review of published clinical trials was performed to determine whether the …
Antiepileptic drug treatment in children with epilepsy
Most children with new-onset epilepsy achieve seizure freedom with appropriate
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …
RCTs with new antiepileptic drugs in children: a systematic review of monotherapy studies and their methodology
A Weijenberg, M Offringa, OF Brouwer… - Epilepsy research, 2010 - Elsevier
Few randomised controlled trials (RCTs) have been performed in which a second-
generation antiepileptic drug (AED) used as monotherapy was compared with placebo or …
generation antiepileptic drug (AED) used as monotherapy was compared with placebo or …
Medical treatment in infants and young children with epilepsy: off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in …
J Sourbron, S Auvin, A Arzimanoglou, JH Cross… - Epilepsia …, 2023 - Wiley Online Library
Abstract Objective Antiseizure medications (ASMs) remain the mainstay of epilepsy
treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which …
treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which …
Development of outcome criteria to measure effectiveness of antiepileptic therapy in children
Purpose Clinical trials of antiepileptic drugs frequently measure outcomes of seizure control,
which demonstrate efficacy. Yet, functional status, quality of life, and long-term treatment …
which demonstrate efficacy. Yet, functional status, quality of life, and long-term treatment …
[HTML][HTML] Efficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy
Ü Yılmaz, TS Yılmaz, G Dizdarer, G Akıncı, O Güzel… - Seizure, 2014 - Elsevier
Purpose Limited data are available for the effectiveness of the antiepileptic drugs in children
in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability …
in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability …