Objective To estimate the comparative efficacy among antiepileptic drugs in the pediatric
population (0‐18 years). Methods Using the Embase and MEDLINE databases, we updated …

Objectives Drug treatment for children with epilepsy should, ideally, be governed by
evidence from adequate and well‐controlled clinical studies. However, these studies are …

Objectives To compare the time to treatment failure, remission and first seizure of 12 AEDs
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …

Aim This study conducted a systematic review evaluating the effectiveness of newer
antiepileptic drugs (AEDs)(namely, lamotrigine, levetiracetam, topiramate, vigabatrin …

Objective: Due to the challenges inherent in performing clinical trials in children, a
systematic review of published clinical trials was performed to determine whether the …

Most children with new-onset epilepsy achieve seizure freedom with appropriate
antiepileptic drugs (AEDs). However, nearly 20% will continue to have seizures despite …

Few randomised controlled trials (RCTs) have been performed in which a second-
generation antiepileptic drug (AED) used as monotherapy was compared with placebo or …

Abstract Objective Antiseizure medications (ASMs) remain the mainstay of epilepsy
treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which …

Purpose Clinical trials of antiepileptic drugs frequently measure outcomes of seizure control,
which demonstrate efficacy. Yet, functional status, quality of life, and long-term treatment …

Purpose Limited data are available for the effectiveness of the antiepileptic drugs in children
in daily clinical practice. The aim of this study was to investigate the efficacy and tolerability …