Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by
the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point …

Sickle cell disease (SCD) is a heterogeneous disorder, with clinical manifestations including
chronic haemolysis, an increased susceptibility to infections and vaso-occlusive …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Objectives: Identify the epidemiology of sickle cell disease. Describe the different types of
sickle cell crises. Review the treatment and management options available for sickle cell …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

Sickle cell disease (SCD) is a monogenic disorder that afflicts approximately 100,000
Americans and millions of people worldwide. It is characterized by hemolytic anemia, vaso …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Background Sickle cell disease (SCD) is a common, severe disorder that includes
congenital hemolytic anemias caused by inherited point mutations in the β-globin gene. 1 …