Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences

R Rizzuto, T Pozzan - Physiological reviews, 2006 - journals.physiology.org
Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling

AJ Laude, AWM Simpson - The FEBS journal, 2009 - Wiley Online Library
Ca2+ regulates a multitude of cellular processes and does so by partitioning its actions in
space and time. In this review, we discuss how Ca2+ responses are constructed from small …

The organisation and functions of local Ca2+ signals

MD Bootman, P Lipp, MJ Berridge - Journal of cell science, 2001 - journals.biologists.com
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of
cellular processes, such as gene transcription, muscle contraction and cell proliferation. The …

Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

AB Parekh - The Journal of physiology, 2008 - Wiley Online Library
In eukaryotic cells, a rise in cytoplasmic Ca2+ can activate a plethora of responses that
operate on time scales ranging from milliseconds to days. Inherent to the use of a …

Calcium microdomains: organization and function

MJ Berridge - Cell calcium, 2006 - Elsevier
Microdomains of Ca2+, which are formed at sites where Ca2+ enters the cytoplasm either at
the cell surface or at the internal stores, are a key element of Ca2+ signalling. The term …

Fundamentals of cellular calcium signaling: a primer

MD Bootman, G Bultynck - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …

Calcium signalling: dynamics, homeostasis and remodelling

MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com
Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

Calcium signalling—an overview

MD Bootman, TJ Collins, CM Peppiatt… - Seminars in cell & …, 2001 - Elsevier
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range
of cellular processes, such as gene transcription (see Mellström and Naranjo, this issue) …

Calcium signalling: a historical account, recent developments and future perspectives

M Brini, E Carafoli* - Cellular and Molecular Life Sciences CMLS, 2000 - Springer
Ca 2+ is a uniquely important messenger that penetrates into cells through gated channels
to transmit signals to a large number of enzymes. The evolutionary choice of Ca 2+ was …

[HTML][HTML] Intracellular Ca2+ sensing: its role in calcium homeostasis and signaling

R Bagur, G Hajnóczky - Molecular cell, 2017 - cell.com
Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …