Inhibition Effects of Nippostrongylus brasiliensis and Its Derivatives against Atherosclerosis in ApoE-/- Mice through Anti-Inflammatory Response

Y Yang, X Ding, F Chen, X Wu, Y Chen, Q Zhang… - Pathogens, 2022 - mdpi.com
Atherosclerosis (AS) is a dominant and growing cause of death and disability worldwide that
involves inflammation from its inception to the emergence of complications. Studies have …

Anti-Inflammatory Responses Produced with Nippostrongylus brasiliensis-Derived Uridine via the Mitochondrial ATP-Sensitive Potassium Channel and Its Anti …

Y Zhang, X Ding, C Yuan, Y Yang, Q Zhang, J Yao… - Biomolecules, 2024 - mdpi.com
Atherosclerosis (AS) has become the leading cause of cardiovascular disease worldwide.
Our previous study had observed that Nippostrongylus brasiliensis (Nb) infection or its …

Filarial extract of Litomosoides sigmodontis induces a type 2 immune response and attenuates plaque development in hyperlipidemic ApoE‐knockout mice

C Kuehn, M Tauchi, R Furtmair, K Urschel… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT A type 1 immune response is involved in atherosclerosis progression, whereas
the role of a type 2 polarization, especially with regard to an enhanced T helper (Th) 2 cell …

Excretory/secretory products from Trichinella spiralis adult worms ameliorate myocardial infarction by inducing M2 macrophage polarization in a mouse model

L Wu, W Yin, J Wen, S Wang, H Li, X Wang, W Zhang… - Parasites & …, 2023 - Springer
Background Ischemia-induced inflammatory response is the main pathological mechanism
of myocardial infarction (MI)-caused heart tissue injury. It has been known that helminths …

Helminth infections and cardiovascular diseases: A role for the microbiota and Mϕs?

JD Lin, P Loke - Journal of Leukocyte Biology, 2021 - academic.oup.com
Cardiovascular diseases are rising in developing countries with increasing urbanization and
lifestyle changes and remains a major cause of death in the developed world. In this mini …

Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease

SM Quinn, K Cunningham, M Raverdeau… - Frontiers in …, 2019 - frontiersin.org
Recent studies have suggested that the innate immune system can display characteristics of
immunological memory and this has been called “innate immune memory” or “trained …

Inonotus hispidus Protects against Hyperlipidemia by Inhibiting Oxidative Stress and Inflammation through Nrf2/NF-κB Signaling in High Fat Diet Fed Mice

Y Zhang, J Hao, Z Liu, Z Li, L Teng, D Wang - Nutrients, 2022 - mdpi.com
Obesity is frequently associated with dysregulated lipid metabolism and lipotoxicity. Inonotus
hispidus (Bull.: Fr.) P. Karst (IH) is an edible and medicinal parasitic mushroom. In this study …

Nocardia brasiliensis induces an immunosuppressive microenvironment that favors chronic infection in BALB/c mice

AG Rosas-Taraco, AR Perez-Liñan… - Infection and …, 2012 - Am Soc Microbiol
Nocardia brasiliensis is an intracellular microorganism and the most common etiologic
agent of actinomycetoma in the Americas. Several intracellular pathogens induce an …

Can worms defend our hearts? Chronic helminthic infections may attenuate the development of cardiovascular diseases

E Magen, G Borkow, Z Bentwich, J Mishal, S Scharf - Medical hypotheses, 2005 - Elsevier
The established risk factors for atherosclerosis fail to fully explain the extent and severity of
coronary artery diseases in 50% of the patients. Thus, the causative agents and processes …

Naoxintong capsule remodels gut microbiota and ameliorates early-stage atherosclerosis in apolipoprotein E-deficient mice

H Wan, Y Lu, J Yang, H Wan, L Yu, N Fang, Y He, C Li - Phytomedicine, 2024 - Elsevier
Background Naoxintong capsule (NXT) is a compound traditional Chinese medicine
prescription with demonstrated effect for the treatment of cardiovascular and …