Within the germinal center in follicles, B-cells proliferate, mutate and differentiate, while
being submitted to a powerful selection: a micro-evolutionary mechanism at the heart of …

The rapid evolution of antibody molecules during an immune response enables the immune
system to respond efficiently to an immense variety of challenges. To investigate this …

During the immune response, the generation of memory B lymphocytes in germinal centers
involves affinity maturation of the cells' antigen receptors, based on somatic hypermutation …

We propose a stochastic framework to describe the evolution of the B-cell repertoire during
germinal center (GC) reactions. Our model is formulated as a multitype age-dependent …

Many events in the vertebrate immune system are influenced by some element of chance.
The objective of the present work is to describe affinity maturation of B lymphocytes (in which …

Affinity maturation, the fundamental basis for adaptive immunity, is accomplished through
somatic hypermutation of B-cell receptors followed by expansion of rare mutants with higher …

The immune system learns from its encounters with pathogens and memorizes its
experiences. One of the mechanisms it uses for this purpose is the intra-individual evolution …

We study the evolution of large but finite asexual populations evolving in fitness landscapes
in which all mutations are either neutral or strongly deleterious. We demonstrate that despite …

The immune response to an acute primary infection is a coupled process of antigen
proliferation, molecular recognition by naive B-cells, and their subsequent proliferation and …

We analyze the interactions between division, mutation and selection in a simplified
evolutionary model, assuming that the population observed can be classified into fitness …