Immunoproteasome is a variant of proteasome with structural differences in 20S subunits
optimizing them for the production of antigenic peptides with higher binding affinity to major …

Cell-mediated immunity is driven by antigenic peptide presentation on major
histocompatibility complex (MHC) molecules. Specialized proteasome complexes called …

Immunoproteasome is an emerging biological target that constitutes a key element not only
in antigen presentation but also in T cell and cytokine regulation as well as cellular …

The proteasome, a large multisubunit protease complex, has been extensively investigated
over the years, greatly enhancing our understanding of critical roles that the proteasome …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein
homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease …

Apart from the constitutive proteasome, the immunoproteasome that comprises the three
proteolytic subunits LMP2, MECL-1, and LMP7 is expressed in most immune cells. In this …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

The immunoproteasome is a proteasome variant that is found only in jawed vertebrates. It is
responsible for degrading intracellular proteins to generate a major source of peptides with …

The participation of proteasomes in vital cellular and metabolic processes that are involved
in tumor growth has made this protease complex an attractive target for cancer treatment. In …