In recent years, small interfering RNA (siRNA) has been widely used in the treatment of
human diseases, especially tumors, and has shown great appeal. However, the clinical …

Small interfering RNA (siRNA) has emerged as a powerful tool in gene therapy to suppress
gene expression. However, the fragile properties of siRNA and the low efficiency with non …

Gene silencing through RNA interference (RNAi), particularly using small double-stranded
RNA (siRNA), has been identified as a potent strategy for targeted cancer treatment. Yet, its …

We report here a novel and personalized strategy of selenium/ruthenium nanoparticles
modified metal organic frameworks MIL-101 (Fe) for delivering pooled small interfering …

Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific
locations in a controlled manner. Here, the study presents a novel nanoplatform constructed …

MicroRNA (miRNA) has been widely used as an effective gene drug for tumor therapy, but
its chemical instability limited its therapeutic application in vivo. In this research, we fabricate …

The combination of gene therapy and chemotherapy has recently received considerable
attention for cancer treatment. However, low transfection efficiency and poor endosomal …

The introduction of different pore diameters in metal organic frameworks (MOFs) could
adjust their drug delivery performance. MOFs with customized structures have potential …

Therapeutic bioactive macromolecules hold great promise in cancer therapy, but challenges
such as low encapsulation efficiency and susceptibility to inactivation during the targeted co …

MicroRNA (miRNA) represents a promising class of therapeutic nucleic acid drugs, while
delivery challenges remain that impede the advancement of miRNA therapy, largely …