The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major
source of central noradrenaline. It remains unclear whether the LC acts functionally as a …

Central noradrenergic centers such as the locus coeruleus (LC) are traditionally viewed as
pain inhibitory; however, complex interactions among brainstem pathways and their …

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces anxiety-
like and aversive behavior. While some information is known about the afferent circuitry that …

Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to
modulate a wide range of processes including attention, arousal, autonomic control and …

The noradrenergic system is crucial for several activities in the body, including the
modulation of pain. As the major producer of noradrenaline (NA) in the central nervous …

There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …

The locus coeruleus (LC) is a critical node in the stress response, and its activation has
been shown to promote hypervigilance and anxiety-like behavior. This noradrenergic …

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

It is well documented that the descending endogenous analgesia system, including the
periaqueductal gray (PAG) and the rostral ventral medulla (RVM), play an important role in …