Sugar-coated RNAs
D Clyde - Nature Reviews Genetics, 2021 - nature.com
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[PDF][PDF] RNA, a new member in the glycan-club that gets exposed at the cell surface
When thinking about glycosylation, we mainly think of proteins or proteoglycans, which is not
surprising as glycosylation is the second most frequent post-translational modification …
surprising as glycosylation is the second most frequent post-translational modification …
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA
We recently identified glycoRNA—a previously undescribed glycoconjugate—which
consists of RNAs modified with secretory N-glycans and presented on the cell surface. While …
consists of RNAs modified with secretory N-glycans and presented on the cell surface. While …
Identification of glycosylated nucleosides in small synthetic glyco‐RNAs
FS Michael, MB Hamouda, J Stupak, J Li… - …, 2024 - Wiley Online Library
Recently, the post‐transcriptional modification of RNA with N‐glycans was reported,
changing the paradigm that RNAs are not commonly N‐glycosylated. Moreover, glycan …
changing the paradigm that RNAs are not commonly N‐glycosylated. Moreover, glycan …
N-glycosylated molecules act as a co-precipitant in RNA purification
A recent ground-breaking study suggested that small RNA from mammalian cells can
undergo N-glycan modifications (termed glycoRNA). The discovery relied upon a metabolic …
undergo N-glycan modifications (termed glycoRNA). The discovery relied upon a metabolic …
Spatial imaging of glycoRNA in single cells with ARPLA
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …
discovered class of glycosylated molecules, because of a lack of visualization methods. We …
New vistas for cell-surface GlycoRNAs
S Nachtergaele, Y Krishnan - New England Journal of Medicine, 2021 - Mass Medical Soc
A New Dimension in the RNA World Discoveries in noncoding RNA have shown it to be
remarkably diverse in function and form and to have relevance in drug development. A …
remarkably diverse in function and form and to have relevance in drug development. A …
Small RNAs are modified with N-glycans and displayed on the surface of living cells
Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
Approach for functional analysis of glycan using RNA interference
S Nishihara, R Ueda, S Goto, H Toyoda, H Ishida… - Glycoconjugate …, 2004 - Springer
The elucidation of the biological role of glycan is one of the most important issues to be
resolved following the genome project. RNA interference is becoming an efficient reverse …
resolved following the genome project. RNA interference is becoming an efficient reverse …