Sugar-coated RNAs

D Clyde - Nature Reviews Genetics, 2021 - nature.com
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[PDF][PDF] RNA, a new member in the glycan-club that gets exposed at the cell surface

E Chevet, MA De Matteis, EL Eskelinen, H Farhan - Traffic, 2021 - utupub.fi
When thinking about glycosylation, we mainly think of proteins or proteoglycans, which is not
surprising as glycosylation is the second most frequent post-translational modification …

The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA

Y Xie, H Hemberger, NA Till, P Chai, CP Watkins… - bioRxiv, 2023 - biorxiv.org
We recently identified glycoRNA—a previously undescribed glycoconjugate—which
consists of RNAs modified with secretory N-glycans and presented on the cell surface. While …

Identification of glycosylated nucleosides in small synthetic glyco‐RNAs

FS Michael, MB Hamouda, J Stupak, J Li… - …, 2024 - Wiley Online Library
Recently, the post‐transcriptional modification of RNA with N‐glycans was reported,
changing the paradigm that RNAs are not commonly N‐glycosylated. Moreover, glycan …

N-glycosylated molecules act as a co-precipitant in RNA purification

S Kim, Y Choi, K Janssen, C Bull, BS Joshi, A Pomorski… - bioRxiv, 2024 - biorxiv.org
A recent ground-breaking study suggested that small RNA from mammalian cells can
undergo N-glycan modifications (termed glycoRNA). The discovery relied upon a metabolic …

Spatial imaging of glycoRNA in single cells with ARPLA

Y Ma, W Guo, Q Mou, X Shao, M Lyu, V Garcia… - Nature …, 2024 - nature.com
Little is known about the biological roles of glycosylated RNAs (glycoRNAs), a recently
discovered class of glycosylated molecules, because of a lack of visualization methods. We …

New vistas for cell-surface GlycoRNAs

S Nachtergaele, Y Krishnan - New England Journal of Medicine, 2021 - Mass Medical Soc
A New Dimension in the RNA World Discoveries in noncoding RNA have shown it to be
remarkably diverse in function and form and to have relevance in drug development. A …

[引用][C] Glycan-RNA: a new class of non-coding RNA

X Li, TJ Loh, JJ Lim, P Er Saw, Y Liao - BIO Integration, 2022 - Compuscript

Small RNAs are modified with N-glycans and displayed on the surface of living cells

RA Flynn, K Pedram, SA Malaker, PJ Batista… - Cell, 2021 - cell.com
Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

Approach for functional analysis of glycan using RNA interference

S Nishihara, R Ueda, S Goto, H Toyoda, H Ishida… - Glycoconjugate …, 2004 - Springer
The elucidation of the biological role of glycan is one of the most important issues to be
resolved following the genome project. RNA interference is becoming an efficient reverse …