Pyrazines are important class of pharmacophores because of their versatility in
pharmacological activity. Pyrazines are among the most widely known heterocyclic …

Heterocycles are significant class of compound in organic chemistry, due to their substantial
pharmacological application and development of new materials, as well as their prevalence …

Pyridazine and pyridazinone are heterocycles that contain two adjacent nitrogen atoms and
shown wide range of pharmacological activities such as antimicrobial, antidepressant anti …

Introduction: Pyrazines derivatives are well-known and important two-nitrogen-containing six-
membered ring aromatic heterocyclic compounds and can carry substituents at one or more …

Nitrogen atom containing heterocycles showed diverse biological properties are important
structural feature of many physiologically active compounds. Pyridazines and phthalazines …

Nitrogen-containing heterocycles were employed in different applications such as
pharmaceuticals, organic materials, natural products, and mainly in bioactive molecules …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

The five membered heterocyclic compounds pyrazolines were found as the core structure in
a large variety of compounds. Pyrazoles have been the recent target of numerous …

Heterocyclic compounds have a wide presence in widely used chemical structures. For
example, we can mention nucleic acids, a wide range of drugs, alkaloids in plants, many …

Introduction: Pyrazine is a member of 1, 4-diazines, which constitute an important class of
heterocycles. Various pyrazine derivatives have been synthesized and successfully …