Neuron–glia interactions play a key role in maintaining and regulating the central nervous
system. Glial cells are implicated in the function of dopamine neurons and regulate their …

To determine the role of immune/inflammatory factors in dopaminergic cell degeneration in
parkinsonian substantia nigra, we assayed tyrosine hydroxylase (TH)-positive …

In neurodegenerative diseases, the inflammatory response is mediated by activated glial
cells, mainly microglia, which are the resident immune cells of the central nervous system …

Neurotoxicity induced by 6-hydroxydopamine (6-OHDA) is believed to be due, in part, to the
production of reactive oxygen species (ROS). Anti-oxidants by inhibiting free radical …

Minocycline has been shown previously to have beneficial effects against ischemia in rats
as well as neuroprotective properties against excitotoxic damage in vitro, nigral cell loss via …

In Parkinson disease (PD), the dopaminergic (DAergic) neurons in the substantia nigra
undergo degeneration. While the exact mechanism for the degeneration is still not …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
cardinal features of tremor, bradykinesia, rigidity and postural instability. In addition to the …

Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of
dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and …

Activated microglia are implicated in the pathogenesis of disease‐, trauma‐and toxicant‐
induced damage to the CNS, and strategies to modulate microglial activation are gaining …

Experimental and clinical studies support the view that the semisynthetic tetracycline
minocycline exhibits neuroprotective roles in several models of neurodegenerative …