[HTML][HTML] Aging and mesenchymal stem cells: basic concepts, challenges and strategies

M Fraile, N Eiro, LA Costa, A Martín, FJ Vizoso - Biology, 2022 - mdpi.com
Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

[HTML][HTML] Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches

SS Lee, TT Vũ, AS Weiss, GC Yeo - European Journal of Cell Biology, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the
treatment of degenerative and inflammatory conditions. However, despite accumulating …

[HTML][HTML] Senescence of mesenchymal stem cells

Y Li, Q Wu, Y Wang, L Li, H Bu… - … journal of molecular …, 2017 - spandidos-publications.com
Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases,
due to their immunomodulatory and inflammatory effects. However, the function of MSCs is …

[HTML][HTML] Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

M Al-Azab, M Safi, E Idiiatullina, F Al-Shaebi… - Cellular & Molecular …, 2022 - Springer
Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies

Z Weng, Y Wang, T Ouchi, H Liu, X Qiao… - Stem Cells …, 2022 - academic.oup.com
Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

[HTML][HTML] Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Aging of mesenchymal stem cells: Implication in regenerative medicine

YHK Yang - Regenerative therapy, 2018 - Elsevier
Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical
applications including regenerative medicine. However, aging both in vivo and in vitro can …

[HTML][HTML] Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Stem cells: Potential therapy for age‐related diseases

M Kassem - Annals of the New York Academy of Sciences, 2006 - Wiley Online Library
Aging is associated with a progressive failing of tissues and organs of the human body
leading to a large number of age‐related diseases. Regenerative medicine is an emerging …

[HTML][HTML] Mesenchymal stem cell senescence and rejuvenation: current status and challenges

X Zhou, Y Hong, H Zhang, X Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …