Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …

Recent genome‐wide studies have revealed that aging or chronic inflammation can cause
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …

Abstract Purpose of Review This article summarizes the current knowledge about clonal
hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease …

Clonal hematopoiesis (CH) defines a population of hematopoietic cells with one or more
somatic mutations/copy number alterations that can expand with time and under positive …

In the multi-hit model of carcinogenesis, a precancerous state often precedes overt
malignancy. Identification of these states has been of great interest as they allow for early …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …

Hematopoietic stem and progenitor cells (HSPCs) acquire somatic mutations with age
resulting in a heterogeneous HSPC population, with each HSPC possessing its own unique …

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …

Clonal hematopoiesis (CH) of indeterminate potential (CHIP), defined as the presence of a
somatic mutation in the peripheral blood at a variant allele frequency (VAF)≥ 2%, affects at …

12003 Background: CHIP is defined by the presence of age-dependent acquired mutations
in hematopoietic progenitor cells and has been reported to occur in up to 30% of individuals …