The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Besides cyclooxygenase and NO-synthase, another distinct endothelial pathway,
endothelium-dependent hyperpolarization (EDHF), is involved in the relaxation of the …

Endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the
release of vasoactive factors. Besides nitric oxide (NO) and prostacyclin, increasing …

The endothelium maintains vascular homeostasis through the release of active vasodilators.
Although nitric oxide (NO) is recognized as the primary factor at level of conduit arteries …

Endothelium-dependent relaxations cannot be fully explained by the release of either NO
or/and prostacyclin. Another unidentified substance (s) which hyperpolarizes the underlying …

Endothelium-dependent hyperpolarization of vascular smooth muscle is a mechanism that
contributes to the vasodilator response to shear stress and chemicals acting on endothelial …

The chemical identification and functional characterization of endothelium-derived
hyperpolarizing factors varies depending on vascular size, vascular bed and species. Three …

Institut de Recherches Internationale Servier, 6 Place des Pleides, 92415 Courbevoie,
Cedex, FranceINTRODUCTIONEndothelial cells synthesise and release vasoactive …

Epoxyeicosatrienoic acids (EETs) are generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases. The expression of CYP epoxygenases in endothelial cells is …