Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways
and play critical roles in a number of physiological and pathological processes including …

FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …

Growing evidence suggests that alterations of gene expression including expression and
activities of transcription factors are closely associated with carcinogenesis. Forkhead Box …

FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …

Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …

Forkhead box O-class (FOXO) transcription factors, including FOXO1, FOXO3a and FOXO4,
function as tumor-suppressor proteins by inhibiting cell proliferation, promoting apoptotic cell …

The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological
processes including cellular energy storage, growth, and survival, among others. As an …

FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …

It is now widely accepted that several gene alterations including transcription factors are
critically involved in cancer progression and metastasis. Forkhead Box Class O proteins …