[HTML][HTML] FOXO signaling pathways as therapeutic targets in cancer
Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …
FOXOs, cancer and regulation of apoptosis
Z Fu, DJ Tindall - Oncogene, 2008 - nature.com
Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways
and play critical roles in a number of physiological and pathological processes including …
and play critical roles in a number of physiological and pathological processes including …
[HTML][HTML] Re-evaluating the role of FOXOs in cancer
FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …
FOXK transcription factors: regulation and critical role in cancer
Y Liu, W Ding, H Ge, M Ponnusamy, Q Wang, X Hao… - Cancer letters, 2019 - Elsevier
Growing evidence suggests that alterations of gene expression including expression and
activities of transcription factors are closely associated with carcinogenesis. Forkhead Box …
activities of transcription factors are closely associated with carcinogenesis. Forkhead Box …
FOXO family in regulating cancer and metabolism
J Ma, S Matkar, X He, X Hua - Seminars in cancer biology, 2018 - Elsevier
FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …
FOXO transcription factors: their clinical significance and regulation
Y Wang, Y Zhou, DT Graves - BioMed research international, 2014 - Wiley Online Library
Members of the class O of forkhead box transcription factors (FOXO) have important roles in
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
metabolism, cellular proliferation, stress resistance, and apoptosis. The activity of FOXOs is …
FOXO factors: a matter of life and death
H Huang, DJ Tindall - Future Oncology, 2006 - Taylor & Francis
Forkhead box O-class (FOXO) transcription factors, including FOXO1, FOXO3a and FOXO4,
function as tumor-suppressor proteins by inhibiting cell proliferation, promoting apoptotic cell …
function as tumor-suppressor proteins by inhibiting cell proliferation, promoting apoptotic cell …
FoxO family members in cancer
The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological
processes including cellular energy storage, growth, and survival, among others. As an …
processes including cellular energy storage, growth, and survival, among others. As an …
FOXO and FOXM1 in cancer: the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy
M SC Wilson, JJ Brosens, H DC Schwenen… - Current drug …, 2011 - ingentaconnect.com
FOXO transcription factors, functioning downstream of the PI3K-PTEN-AKT (PKB) signalling
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …
cascade, are essential for cell proliferation, differentiation, DNA damage repair and …
Role of Forkhead Box Class O proteins in cancer progression and metastasis
It is now widely accepted that several gene alterations including transcription factors are
critically involved in cancer progression and metastasis. Forkhead Box Class O proteins …
critically involved in cancer progression and metastasis. Forkhead Box Class O proteins …