EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8

Y Zhao, L Sui, P Wu, L Li, L Liu, B Ma, W Wang… - Journal of …, 2023 - Am Soc Microbiol
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has led to an unprecedented public health crisis worldwide. Though the host …

Multiple E3 ligases act as antiviral factors against SARS-CoV-2 via inducing the ubiquitination and degradation of ORF9b

M Yu, J Li, W Gao, Z Li, W Zhang - Journal of Virology, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) open reading frame 9b
(ORF9b) antagonizes the antiviral type I and III interferon (IFN) responses and is …

The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation

Z Li, P Hao, Z Zhao, W Gao, C Huan, L Li… - … and Targeted Therapy, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …

SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense

X Ju, Z Wang, P Wang, W Ren, Y Yu, Y Yu, B Yuan… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the
global pandemic of COVID-19. SARS-CoV-2 genome encodes a main protease (nsp5, also …

UBR5 acts as an antiviral host factor against MERS-CoV via promoting ubiquitination and degradation of ORF4b

Y Zhou, R Zheng, D Liu, S Liu, C Disoma, S Li… - Journal of …, 2022 - Am Soc Microbiol
Within the past 2 decades, three highly pathogenic human coronaviruses have emerged,
namely, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East …

The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein

C Zou, H Yoon, PMC Park, JJ Patten, J Pellman… - Iscience, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human
proteins during infection and viral replication. To examine whether any viral proteins employ …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) and spike (S) proteins antagonize host type I interferon response

Q Zhang, Z Chen, C Huang, J Sun, M Xue… - Frontiers in cellular …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has spread worldwide and has infected more than 250 million …

Functional landscape of SARS-CoV-2 cellular restriction

L Martin-Sancho, MK Lewinski, L Pache, CA Stoneham… - Molecular cell, 2021 - cell.com
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …

The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication

J Li, Q Gui, FX Liang, J Sall, Q Zhang, Y Duan… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses,
replicates their genome in virus-induced cytosolic membrane-bound replication organelles …

NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity

X Lv, R Chen, T Liang, H Peng, Q Fang, S Xiao, S Liu… - Mbio, 2024 - Am Soc Microbiol
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
triggered a global pandemic, which severely endangers public health. Our and others' works …