Purpose: Pancreatic cancer is characterized by intratumoral hypoxia, early and aggressive
local invasion, and metastatic potential. Hypoxia-inducible factor-1 (HIF-1) is the major …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

MATERIALS AND METHODS: To address this shortcoming, we used both in vitro and in vivo
approaches to evaluate the overall effects of HIF-1alpha on pancreatic cancer. We used a …

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …

Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging
diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor …

In the tumor cells exposed to hypoxia, hypoxia-inducible factor-1 (HIF-1)-mediated
adaptation responses such as angiogenesis and anaerobic metabolism are induced for their …

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Objectives: The aim of the study was to observe the effect of antisense hypoxia-inducible
factor 1α (HIF-1α) on progression, metastasis, and chemosensitivity of pancreatic cancer …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal digestive tract
malignancies. Hypoxia-inducible factor (HIF-1) is over-expressed in pancreatic cancer and …

The microenvironment of solid tumors is characterized by low pO 2 that is well below
physiological levels. Intratumoral hypoxia is a major factor contributing to cancer …