Glucocorticoids play an important biphasic role in modulating neural plasticity; low doses
enhance neural plasticity and spatial memory behavior, whereas chronic, higher doses …

Glucocorticoids have long been recognized for their role in regulating the availability of
energetic resources, particularly during stress. Furthermore, bidirectional connections …

It has become increasingly clear that glucocorticoid (GC) signaling not only comprises
classic nuclear receptor binding—that is, glucocorticoid receptors (GRs) to their response …

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …

Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demand
and an inability to proliferate. Therefore, dysfunctional mitochondria cause various …

Glucocorticoids have a bimodal effect on cognition, hippocampal pyramidal neurons and
long-term potentiation (LTP). Transient increases in glucocorticoids improve performance at …

Glucocorticoids, the adrenal steroids secreted during stress, while critical for successful
adaptation to acute physical stressors, can have a variety of deleterious effects if secreted in …

Glucocorticoids (GCs) can damage neurons of the hippocampus, the principal target tissue
in the brain for the hormone. Hippocampal neuron loss during aging in the rat is accelerated …

The link between chronic psychosocial and metabolic stress and the pathogenesis of
disease has been extensively documented. Nevertheless, the cellular mechanisms by which …

Both chronic mild stress and an injection of corticosterone induce depression-like states in
rodents. To further link mitochondrial dysfunction to the pathophysiology of major …