p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a
broad range of genes to modulate a series of cellular events, including DNA damage repair …

The p53 tumor suppressor potently limits the growth of immature and mature neurons under
conditions of cellular stress. Although loss of p53 function contributes to the pathogenesis of …

The p53 tumor suppressor gene (TP53) is the most frequently altered gene in human cancer
and is also found mutated in several types of brain tumors. Loss of p53 function plays a …

Emerging evidence suggests that p53, a tumor suppressor protein primarily involved in
cancer biology, coordinates a wide range of novel functions in the CNS including the …

This article reviews the recent molecular and clinical studies that characterize the role of p53
in pathologies of the central nervous system, p53 has many important biological functions …

More than thirty years elapsed since a protein, not yet called p53 at the time, was detected to
bind SV40 during viral infection. Thousands of papers later, p53 evolved as the main tumor …

In the two decades since its original discovery, p53 has found a singularly prominent place
in our understanding of human cancer. Although the biochemistry of p53 has been worked …

Malignant glioma is the most common brain tumor in adults and is associated with a very
poor prognosis. Mutations in the p53 tumor suppressor gene are frequently detected in …

Mutations in the TP53 gene or the p53 pathway are required for the formation of many
human cancers, including brain tumors. The p53 protein is a multi-modal tumor suppressor …

The transcription factor p53 protects neurons from transformation and DNA damage through
the induction of cell‐cycle arrest, DNA repair and apoptosis in a range of in vitro and in vivo …