Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics
R Chaudhuri, S Bhattacharya, J Dash… - Journal of Medicinal …, 2020 - ACS Publications
Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …
Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer
DSH Chan, H Yang, MHT Kwan, Z Cheng, P Lee… - Biochimie, 2011 - Elsevier
G-quadruplexes are non-canonical DNA secondary structures putatively present in the
promoter regions of oncogenes in the human genome. The targeting of promoter G …
promoter regions of oncogenes in the human genome. The targeting of promoter G …
Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
J Dickerhoff, J Dai, D Yang - Nucleic Acids Research, 2021 - academic.oup.com
Abstract DNA G-Quadruplexes (G4s) formed in oncogene promoters regulate transcription.
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
The oncogene MYC promoter G4 (MycG4) is the most prevalent G4 in human cancers …
[HTML][HTML] Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …
Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
[PDF][PDF] G-Quadruplex: a regulator of gene expression and its chemical targeting
Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast …
W Long, BX Zheng, Y Li, XH Huang, DM Lin… - Nucleic acids …, 2022 - academic.oup.com
DNA G4-structures from human c-MYC promoter and telomere are considered as important
drug targets; however, the developing of small-molecule-based fluorescent binding ligands …
drug targets; however, the developing of small-molecule-based fluorescent binding ligands …
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
W Wang, S Hu, Y Gu, Y Yan, DB Stovall, D Li… - Biochimica et Biophysica …, 2020 - Elsevier
Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …
Solution structure of a 2: 1 quindoline–c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design
Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
promoters. The nuclease hypersensitivity element III1 (NHE III1) of the c-MYC promoter can …
[HTML][HTML] G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy
A Awadasseid, X Ma, Y Wu, W Zhang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract G-quadruplexes (G4) are secondary four-stranded DNA helical structures
consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of …
consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of …