Characterisation of degradation products of tegoprazan by LC-MS and GC-MS

K Guo, X He, H Zhao, C Ma - Journal of Pharmaceutical and Biomedical …, 2023 - Elsevier
Tegoprazan is a novel orally active potassium-competitive acid blocker (P-CAB), capable of
binding to the K+ binding site of H+/K+-ATPase in a reversible way to inhibit gastric acid …

Simultaneous quantification of tegoprazan and its major metabolite M1 in dog plasma using liquid chromatography-tandem mass spectrometry

J Kim, S Kim, HJ Noh, SY Ryu, SJ Kim - Journal of Pharmaceutical and …, 2019 - Elsevier
Tegoprazan is a novel potassium-competitive acid blocker (P-CAB) recently approved in
Korea as a next-generation therapeutics for gastric acid-related diseases. In the present …

Effects of tegoprazan, a novel potassium-competitive acid blocker, on rat models of gastric acid–related disease

DK Kim, KH Lee, S Kim, SJ Kim, SJ Lee, CH Park… - … of Pharmacology and …, 2019 - ASPET
Tegoprazan, a novel potassium-competitive acid blocker (P-CAB), is a next-generation
therapeutics developed for the treatment of acid-related gastrointestinal diseases such as …

Tegoprazan as a New Remedy for Gastrointestinal Diseases in Comparison with its Therapeutic Predecessors: A Mini-Review

AH Anik, FA Proma, P Saha… - Current Drug Research …, 2024 - ingentaconnect.com
Potassium-competitive acid blockers (P-CABs), such as tegoprazan, are a new and diverse
class of drugs that can completely block the potassium-binding site of gastric H+/K+ ATPase …

Randomised clinical trial: safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of tegoprazan (CJ‐12420), a novel …

S Han, HY Choi, YH Kim, JY Nam, B Kim… - Alimentary …, 2019 - Wiley Online Library
Summary Background Tegoprazan (CJ‐12420) is a potassium‐competitive acid blocker (P‐
CAB) with therapeutic potential for gastro‐oesophageal reflux disease (GERD) by reversibly …

Pharmacokinetic and pharmacodynamic exploration of various combinations of tegoprazan immediate and delayed‐release formulations

S Park, E Yang, B Kim, J Kwon… - British Journal of …, 2023 - Wiley Online Library
Aims The new modified‐release formulation of tegoprazan, a novel potassium‐competitive
acid blocker, is expected to improve the management of acid‐related disease, including …

Manufacturing Process Development of Tegoprazan as a Potassium-Competitive Acid Blocker (P-CAB)

JH Kweon, H Shin, MK Lee, SA Lee… - … Process Research & …, 2024 - ACS Publications
Tegoprazan, a selective potassium-competitive acid blocker, was approved in 2018 in the
Republic of Korea for the treatment of gastroesophageal reflux disease (GERD), erosive …

[引用][C] Safety, tolerability, pharmacokinetics, and pharmacodynamics of escalating single and multiple oral doses of CJ-12420 (tegoprazan), a novel potassium …

S Han, HY Choi, YH Kim, JY Nam… - Clinical …, 2017 - clinicaltherapeutics.com
Background CJ-12420 (tegorazan) is a promising potassium-competitive acid blocker (P-
CAB) with therapeutic potential for gastroesophageal reflux disease (GERD) by reversibly …

[PDF][PDF] Comparison of pharmacokinetic characteristics of two Tegoprazan (CJ-12420) formulations in healthy male subjects

JG Hwang, H Yoo, JW Lee, GS Song… - Translational and …, 2019 - synapse.koreamed.org
Proton-pump inhibitors (PPIs) are effectively used to treat acid-related diseases, including
gastroesophageal reflux disease (GERD); however, many unmet medical needs still exist …

Effect of meal timing on pharmacokinetics and pharmacodynamics of tegoprazan in healthy male volunteers

DY Yoon, J Sunwoo, N Shin, AR Kim… - Clinical and …, 2021 - Wiley Online Library
Tegoprazan, a novel potassium‐competitive acid blocker, is used to treat acid‐related
diseases. However, there is no information on the pharmacokinetic (PK) and …