Dwarf mice are remarkably long-lived. Congenital deficiency of growth hormone (GH),
prolactin, and thyroid-stimulating hormone (TSH) due to mutations at the Pit1 or Prop1 loci …

Background Long-lived strains of dwarf mice carry mutations that suppress growth hormone
(GH) and insulin-like growth factor I (IGF-I) signaling. The downstream effects of these …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …

In two types of mutant dwarf mice, congenital deficiencies in pituitary function are associated
with remarkably increased life expectancy. In this review, we will describe the key …

Single-gene mutations that extend lifespan provide valuable tools for the exploration of the
molecular basis for age-related changes in cell and tissue function and for the …

Over the past 30 years, the Snell dwarf mutation (Pit1dw) has been reported to shorten, to
have no effect on, or to increase life span in various colonies; however, few details of these …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

Studies in invertebrates have led to the identification of a number of genes that regulate
lifespan, some of which encode components of the insulin or insulin-like signalling …

Inhibiting insulin/IGF-1 signalling extends lifespan and delays age-related disease in
species throughout the animal kingdom. This life-extension pathway, the first to be defined …

Snell dwarf mice have multiple hormonal deficits, but the way in which these deficits
postpone aging are still uncertain. In this study, Snell dwarf mice received 11 weeks of …